Stannous Chloride → 4-(4-chloro-1H-1,2,3-triazol-1-yl)aniline

HRID 40736노트

반응식

HRID 40736 반응식
[Cl:1][C:2]1[N:3]=[N:4][N:5]([C:7]2[CH:12]=[CH:11][C:10]([N+:13]([O-])=O)=[CH:9][CH:8]=2)[CH:6]=1.Cl[Sn]Cl>C(O)C>[Cl:1][C:2]1[N:3]=[N:4][N:5]([C:7]2[CH:12]=[CH:11][C:10]([NH2:13])=[CH:9][CH:8]=2)[CH:6]=1

참가 물질

4

반응물 2

HCID 24479Stannous ChlorideHCID 687732414-chloro-1-(4-nitrophenyl)-1H-1,2,3-triazole

생성물 1

HCID 595880664-(4-chloro-1H-1,2,3-triazol-1-yl)aniline

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
85 °C

실험 절차

To a solution of 4-chloro-1-(4-nitrophenyl)-1H-1,2,3-triazole (0.1 g, 0.45 mmol) in ethanol (3 mL) was added SnCl2 (0.4 g, 1.8 mmol) portionwise. The slurry was warmed up to 85° C. for 2.5 h, then quenched with NaOH (2M), filtered and concentrated. The residue was redissolved in EtOAc and washed with brine. The organic layer was separated, dried (MgSO4), and concentrated to afford 4-(4-chloro-1H-1,2,3-triazol-1-yl)aniline.

후처리

  1. customquenched with NaOH (2M)
  2. filtrationfiltered
  3. concentrationconcentrated
  4. dissolutionThe residue was redissolved in EtOAc
  5. washwashed with brine
  6. customThe organic layer was separated
  7. dry with materialdried (MgSO4)
  8. concentrationconcentrated

출처 및 근거

ORD 기록
ord-aa327e72d6a445cda4d6f8ffc6eb3592
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08530480B2

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