2-Amino-2-methyl-1-propanol → 4-tert-Butyl-N-(2-hydroxy-1,1-dimethyl-ethyl)-benzamide

HRID 407600

반응식

HRID 407600 반응식
[C:1]([C:5]1[CH:13]=[CH:12][C:8]([C:9](Cl)=[O:10])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[NH2:14][C:15]([CH3:19])([CH3:18])[CH2:16][OH:17]>C(Cl)Cl>[C:1]([C:5]1[CH:13]=[CH:12][C:8]([C:9]([NH:14][C:15]([CH3:19])([CH3:18])[CH2:16][OH:17])=[O:10])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]

참가 물질

4

반응물 2

HCID 118072-Amino-2-methyl-1-propanolHCID 743724-tert-Butylbenzoyl chloride

생성물 1

HCID 3200764-tert-Butyl-N-(2-hydroxy-1,1-dimethyl-ethyl)-benzamide

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

A solution of 101a in DCM (200 mL) was added to a solution of 2-amino-2-methyl-1-propanol (1000 g, 10.5 mol) in CH2Cl2 (2000 mL) dropwise at 0-10° C. A white precipitate formed 5 minutes after the initial addition. The resulting slurry was stirred at room temperature overnight. The solid was removed by filtration and washed with CH2Cl2 (1000 mL). The filtrate was concentrated on by rotary evaporation to give 101b as a light yellow resin which was used in the next step without further purification.

후처리

  1. customA white precipitate formed 5 minutes after the initial
  2. additionaddition
  3. customThe solid was removed by filtration
  4. washwashed with CH2Cl2 (1000 mL)
  5. concentrationThe filtrate was concentrated on by rotary evaporation

출처 및 근거

ORD 기록
ord-47edd1bf7e7d42f39019402a8a652c8c
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08754077B2

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