Sodium borohydride → 1-(1-(2-Bromoethyl)-3-(2,5-dimethyl-1H-pyrrol-1-yl)-1H-pyrazol-5-yl)ethanol

HRID 407786노트

반응식

HRID 407786 반응식
[Br:1][CH2:2][CH2:3][N:4]1[C:8]([C:9](=[O:11])[CH3:10])=[CH:7][C:6]([N:12]2[C:16]([CH3:17])=[CH:15][CH:14]=[C:13]2[CH3:18])=[N:5]1.[BH4-].[Na+]>CO>[Br:1][CH2:2][CH2:3][N:4]1[C:8]([CH:9]([OH:11])[CH3:10])=[CH:7][C:6]([N:12]2[C:16]([CH3:17])=[CH:15][CH:14]=[C:13]2[CH3:18])=[N:5]1

참가 물질

4

반응물 2

HCID 4311764Sodium borohydrideHCID 866840481-(1-(2-Bromoethyl)-3-(2,5-dimethyl-1H-pyrrol-1-yl)-1H-pyrazol-5-yl)ethanone

생성물 1

HCID 866840491-(1-(2-Bromoethyl)-3-(2,5-dimethyl-1H-pyrrol-1-yl)-1H-pyrazol-5-yl)ethanol

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

A 100-mL round-bottomed flask equipped with a magnetic stirrer was charged with 150e (2.1 g, 1.0 eq., 6.8 mmol), NaBH4 (1.29 g, 5.0 eq., 34.0 mmol), and methanol (50 mL). The mixture was stirred at room temperature for 2 h and quenched with water (30 mL). It was then concentrated under reduced pressure and the residue was extracted with dichloromethane (3×50 mL). The combined organic layer was concentrated under reduced pressure to afford crude 150f, which was used in the next step without further purification. MS-ESI: [M+H]+ 311.9

후처리

  1. customA 100-mL round-bottomed flask equipped with a magnetic stirrer
  2. customquenched with water (30 mL)
  3. concentrationIt was then concentrated under reduced pressure
  4. extractionthe residue was extracted with dichloromethane (3×50 mL)
  5. concentrationThe combined organic layer was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-1b2973b375874fa7ae320dc14178c2a1
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08754077B2

반응 노트

불러오는 중…