Phenol, 2-fluoro-5-methyl- → 4-Bromo-2-fluoro-5-methylphenol

HRID 407981노트

반응식

HRID 407981 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH3:8])=[CH:4][C:3]=1[OH:9].[Br-:10].[Br-].[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.C([N+](CCCC)(CCCC)CCCC)CCC.C([N+](CCCC)(CCCC)CCCC)CCC>C(Cl)(Cl)Cl>[Br:10][C:6]1[C:5]([CH3:8])=[CH:4][C:3]([OH:9])=[C:2]([F:1])[CH:7]=1

참가 물질

4

반응물 2

HCID 182387Phenol, 2-fluoro-5-methyl-HCID 23500184Tetra-n-butylammonium tribromide

생성물 1

HCID 108997434-Bromo-2-fluoro-5-methylphenol수율 96%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

2-Fluoro-5-methylphenol (5.0 g, 40 mmol) was dissolved in chloroform (200 mL). Tetrabutylammonium tribromide (19 g, 40 mmol) was added and the reaction stirred at ambient temperature for 30 minutes. The reaction was concentrated and purified over silica gel (20% EtOAc in hexanes) to afford 4-bromo-2-fluoro-5-methylphenol (7.8 g, 38 mmol, 96% yield) as an amber oil.

후처리

  1. concentrationThe reaction was concentrated
  2. custompurified over silica gel (20% EtOAc in hexanes)

출처 및 근거

ORD 기록
ord-9bc38907ef0b4dfca8248dd9330b26ec
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08754226B2

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