HCID 86648151, 화합물 → HCID 178518923, 화합물
반응식
C(O)(=O)/C=C/C(O)=O.[Cl:9][C:10]1[N:15]=[N:14][C:13]([O:16]C(O)C)=[C:12]([N:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)[CH:11]=1>Br>[Cl:9][C:10]1[N:15]=[N:14][C:13]([OH:16])=[C:12]([N:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)[CH:11]=1참가 물질
3
실험 절차
15 g (6-chloro-4-piperazin-1-yl-pyridazin-3-yloxy)-ethanol fumarate are suspended in 90 ml hydrogen bromide (48%). The reaction mixture is stirred for 1 hour at reflux temperature and evaporated to dryness. 19 g product are obtained as the hydrobromide. M.p.=35° C.
후처리
- temperatureat reflux temperature
- customevaporated to dryness
출처 및 근거
- ORD 기록
- ord-990fe310572d46c686d659d736a3b3d8
- 출처 데이터셋
- uspto-grants-2014_06
- 특허 번호
- US08759326B2
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