Acetic Anhydride → N-(2-Fluorophenyl)acetamide
반응식
C(O[C:5](=[O:7])[CH3:6])(=O)C.[F:8][C:9]1[CH:15]=[CH:14][CH:13]=[CH:12][C:10]=1[NH2:11]>O>[C:5]([NH:11][C:10]1[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=1[F:8])(=[O:7])[CH3:6]참가 물질
4
실험 절차
Acetic anhydride (57 mL, 0.6 mol) was added slowly, over approximately 40 min, to stirred 2-fluoroaniline (27, 55.7 g, 0.5 mol) under cooling (water bath) to maintain the reaction temperature at 60° C. to 70° C. After 10 hours more, the reaction mixture was poured into H2O, the whole was extracted with ethyl acetate (2×300 mL). The combined organic extracts were washed with 5% aqueous NaHCO3, brine, dried (K2CO3), filtered and concentrated to provide the title compound as a white solid (67.0 g, 88%).
후처리
- temperatureto maintain the reaction temperature at 60° C. to 70° C
- extractionthe whole was extracted with ethyl acetate (2×300 mL)
- washThe combined organic extracts were washed with 5% aqueous NaHCO3, brine
- dry with materialdried (K2CO3)
- filtrationfiltered
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-a5aa74e6c47942a594e2d3676c1b0851
- 출처 데이터셋
- uspto-grants-2014_06
- 특허 번호
- US08759336B2
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