Isopropanol → 5-chloro-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-amine

HRID 408423노트

반응식

HRID 408423 반응식
[Cl:1][C:2]1[C:3]([F:14])=[C:4]2[C:10]([N+:11]([O-])=O)=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1.CC(O)C>C1COCC1.[Pt]>[Cl:1][C:2]1[C:3]([F:14])=[C:4]2[C:10]([NH2:11])=[CH:9][NH:8][C:5]2=[N:6][CH:7]=1

참가 물질

5

반응물 2

HCID 3776IsopropanolHCID 602052745-chloro-4-fluoro-3-nitro-1H-pyrrolo[2,3-b]pyridine

생성물 1

HCID 581955655-chloro-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-amine수율 108.1%

시약·촉매·용매 2

HCID 23939Platinum촉매HCID 8028Tetrahydrofuran용매

실험 절차

5-Chloro-4-fluoro-3-nitro-1H-pyrrolo[2,3-b]pyridine (1.00 g, 4.6 mmol) and platinum-0.5% Fe (0.452 g, 0.06 mmol) were suspended in THF (12.4 mL) with IPA (6.2 mL). The mixture was hydrogenated at 20 psi for 20 hours, and then the catalyst was removed by filtration. The filtrate was concentrated to dryness, and 5-chloro-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-amine (923 mg, 107% yield) was isolated as a solid.

후처리

  1. customthe catalyst was removed by filtration
  2. concentrationThe filtrate was concentrated to dryness

출처 및 근거

ORD 기록
ord-1879bd2d58764bfa9f747cc9ba874e86
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08758830B2

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