Sulfuric acid magnesium salt (1:1) → 4-[(Benzofuran-6-ylmethyl)-amino]-butyric acid ethyl ester

온도

20 °C

To a solution of 4-amino-butyric acid ethyl ester hydrochloride (1 eq.) in THF was added TEA (2.5 eq.). The mixture was stirred 5 min at 20° C., then benzofuran-6-carbaldehyde (0.95 eq.) and MgSO4 (3 eq.) were added. The reaction was refluxed for 2 h, then cooled to 20° C. and filtered. The filtrate was added to a suspension of NaBH4 (2 to 6 eq.) in MeOH at −15° C. The reaction was stirred for 2 h at −15° C. The reaction was quenched with the addition of aqueous HCl 2N until pH=2. The aqueous layer was washed twice with EtOAc. The organic layers were discarded. Solid KOH was added to the aqueous layer. The crude was extracted three times with EtOAc. The organic layers were combined, dried over MgSO4, filtered and concentrated under reduced pressure at 20° C. The crude was purified by chromatography on silica gel (elution with DCM/MeOH: 95/5) to afford 4-[(benzofuran-6-ylmethyl)-amino]-butyric acid ethyl ester.

1. temperatureThe reaction was refluxed for 2 h
2. temperaturecooled to 20° C.
3. filtrationfiltered
4. stirringThe reaction was stirred for 2 h at −15° C
5. customThe reaction was quenched with the addition of aqueous HCl 2N until pH=2
6. washThe aqueous layer was washed twice with EtOAc
7. additionSolid KOH was added to the aqueous layer
8. extractionThe crude was extracted three times with EtOAc
9. dry with materialdried over MgSO4
10. filtrationfiltered
11. concentrationconcentrated under reduced pressure at 20° C
12. customThe crude was purified by chromatography on silica gel (elution with DCM/MeOH: 95/5)

ORD 기록

ord-ac60bff47ab3460f836ac051f1ee32e2

출처 데이터셋

uspto-grants-2014_06

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US08759334B2