Hydrochloric Acid → Methyl 2-(4-hydroxyphenoxy)acetate

HRID 408671

반응식

HRID 408671 반응식
C([O:4][C:5]1[CH:16]=[CH:15][C:8]([O:9][CH2:10][C:11]([O:13][CH3:14])=[O:12])=[CH:7][CH:6]=1)(=O)C.C[O-].[Na+].Cl>CO>[OH:4][C:5]1[CH:6]=[CH:7][C:8]([O:9][CH2:10][C:11]([O:13][CH3:14])=[O:12])=[CH:15][CH:16]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 10942334Sodium MethoxideHCID 20717764Methyl (4-acetoxy-phenoxy)-acetate

생성물 1

HCID 602731Methyl 2-(4-hydroxyphenoxy)acetate수율 85%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a 100 ml round flask were added 1.512 g methyl (4-acetoxy-phenoxy)-acetate dissolved in 50 ml anhydrous methanol, 0.364 g sodium methoxide. The mixture was stirred at room temperature for 1 hour. To the stirred mixture was added dilute HCl to adjust pH to weak acidity. The solvent was removed by evaporation. To the residue was added water. The solution was extracted with ethyl acetate for three times. The extract was dried, filtrated and evaporated to obtain 1.004 g of a brown solid, yield 85%. 1H-NMR (400 MHz, DMSO-d6, δ ppm) δ 3.679 (3H, s), 4.646 (2H, s), 6.672 (2H, d), 6.754 (2H, d), 9.0 (1H, s).

후처리

  1. customThe solvent was removed by evaporation
  2. additionTo the residue was added water
  3. extractionThe solution was extracted with ethyl acetate for three times
  4. customThe extract was dried
  5. filtrationfiltrated
  6. customevaporated

출처 및 근거

ORD 기록
ord-c36ed3d2892942d79344c5d41152f084
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08759355B2

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