Hydrochloric Acid → 1-(2-Fluoroethyl)piperazine dihydrochloride

HRID 408812노트

반응식

HRID 408812 반응식
[ClH:1].O1CCOCC1.C(OC([N:15]1[CH2:20][CH2:19][N:18]([CH2:21][CH2:22][F:23])[CH2:17][CH2:16]1)=O)(C)(C)C>ClCCl>[ClH:1].[ClH:1].[F:23][CH2:22][CH2:21][N:18]1[CH2:19][CH2:20][NH:15][CH2:16][CH2:17]1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 21082715tert-Butyl 4-(2-fluoroethyl)piperazine-1-carboxylate

생성물 1

HCID 665456881-(2-Fluoroethyl)piperazine dihydrochloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Add 4 N HCl in 1,4-dioxane (21.52 mL, 86.1 mmol) to a stirred solution of 4-(2-fluoro-ethyl)-piperazine-1-carboxylic acid tert-butyl ester (2.00 g, 8.61 mmol) in dry dichloromethane (60 mL) at room temperature under nitrogen. Stir overnight under nitrogen. Concentrate the reaction under reduced pressure to afford the title compound (1.78 g). ES/MS m/z 133 (M+1).

후처리

  1. concentrationConcentrate
  2. customthe reaction under reduced pressure

출처 및 근거

ORD 기록
ord-1cfc899297914db39f4a9a1200e8a672
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08759360B2

반응 노트

불러오는 중…