Potassium Hydroxide → Potassium 4-hydroxy-2,2-dimethylbutyrate

HRID 409478

반응식

HRID 409478 반응식
[CH3:1][C:2]1([CH3:8])[CH2:6][CH2:5][O:4][C:3]1=[O:7].[OH-:9].[K+:10]>C1C=CC2C(C3C=CC(O)=CC=3)(C3C=CC(O)=CC=3)OC(=O)C=2C=1.CCO.O>[OH:4][CH2:5][CH2:6][C:2]([CH3:8])([CH3:1])[C:3]([O-:9])=[O:7].[K+:10]

참가 물질

5

반응물 2

HCID 14797Potassium HydroxideHCID 947462,2-Dimethyl-4-butyrolactone

생성물 1

HCID 23712640Potassium 4-hydroxy-2,2-dimethylbutyrate수율 71.1%

시약·촉매·용매 2

HCID 4764Phenolphthalein촉매HCID 19096565Water ethanol용매

반응 조건

온도
105 °C

실험 절차

A mixture of dihydro-3,3-dimethyl-2(3H)-furanone (10 mmol; 1.14 g), aqueous 1 M KOH solution (10 mmol) and one drop of phenolphthalein indicator (0.5% w/v in EtOH/water (1:1)) is stirred at 105° C. for 3.5 hours. The mixture is cooled to ambient temperature and concentration under reduced pressure. To the residue is added 10 mL of EtOH. To the solution is added 50 ml of Et2O, and the solid isolated by filtration and dried under 100 mbar at 50° C. to give potassium 4-hydroxy-2,2-dimethylbutyrate (1.21 g, 71%).

후처리

  1. temperatureThe mixture is cooled to ambient temperature
  2. concentrationconcentration under reduced pressure
  3. additionTo the residue is added 10 mL of EtOH
  4. additionTo the solution is added 50 ml of Et2O
  5. customthe solid isolated by filtration
  6. customdried under 100 mbar at 50° C.

출처 및 근거

ORD 기록
ord-35ae9b314b1645268a359b196c797298
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08759365B2

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