Lithium hydroxide, monohydrate → 2-(4-Iodophenyl)propanoic acid

HRID 409716

반응식

HRID 409716 반응식
O.[OH-].[Li+].C[O:5][C:6](=[O:16])[CH:7]([C:9]1[CH:14]=[CH:13][C:12]([I:15])=[CH:11][CH:10]=1)[CH3:8]>O.C1COCC1.CO>[I:15][C:12]1[CH:11]=[CH:10][C:9]([CH:7]([CH3:8])[C:6]([OH:16])=[O:5])=[CH:14][CH:13]=1

참가 물질

6

반응물 2

HCID 168937Lithium hydroxide, monohydrateHCID 10589545Methyl 2-(4-iodophenyl)propanoate

생성물 1

HCID 152255732-(4-Iodophenyl)propanoic acid

시약·촉매·용매 3

HCID 887Methanol용매HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

0.610 g (14.6 mmol) Lithiumhydroxide monohydrate in 15 mL water are added to 2.12 g (7.31 mmol) 2-(4-iodo-phenyl)-propionic acid methyl ester (Bioorg. Med. Chem. Lett. 2010, 20, 896) in 20 mL THF and 12 mL MeOH at 0° C. Cooling is removed and the mixture is stirred at rt for 2 h. After that time, the mixture is acidified with 1 N HCl to pH˜1 and extracted with DCM. The organic layer is washed with brine, dried over sodium sulphate and the solvent is evaporated. The product is used without further purification in Example IV.1.

후처리

  1. temperatureCooling
  2. customis removed
  3. extractionextracted with DCM
  4. washThe organic layer is washed with brine
  5. dry with materialdried over sodium sulphate
  6. customthe solvent is evaporated

출처 및 근거

ORD 기록
ord-c2a403cc04d34e08a6473cf5b7c8264e
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08759528B2

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