Hydrazine → Isoquinoline-3-carbohydrazide

HRID 409748

반응식

HRID 409748 반응식
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]([C:11]([O:13]C)=O)[N:2]=1.[NH2:15][NH2:16]>C(O)C>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[C:3]([C:11]([NH:15][NH2:16])=[O:13])[N:2]=1

참가 물질

4

반응물 2

HCID 9321HydrazineHCID 725374Methyl 3-isoquinolinecarboxylate

생성물 1

HCID 55263898Isoquinoline-3-carbohydrazide수율 86%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of methyl isoquinoline-3-carboxylate (10 g, 53.42 mmol) in ethanol (100 mL) was added hydrazine (17.1 g). The reaction mixture was refluxed for 30 min and concentrated under high vacuum to remove hydrazine. The resulting residue was triturated with ethanol (20 mL) to give isoquinoline-3-carbohydrazide (8.6 g, 86%). LRMS (M+H+) m/z 188.1.

후처리

  1. temperatureThe reaction mixture was refluxed for 30 min
  2. concentrationconcentrated under high vacuum
  3. customto remove hydrazine
  4. customThe resulting residue was triturated with ethanol (20 mL)

출처 및 근거

ORD 기록
ord-4011f0480f4e446aa3625771427965f9
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08759374B2

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