Hydrochloric Acid → 4-(2-Hydroxyethyl)cyclohexan-1-one
반응식
[O:1]1[C:5]2([CH2:10][CH2:9][CH:8]([CH2:11][CH2:12][OH:13])[CH2:7][CH2:6]2)OCC1.C1COCC1.Cl.C([O-])(O)=O.[Na+]>CC(C)=O>[OH:13][CH2:12][CH2:11][CH:8]1[CH2:9][CH2:10][C:5](=[O:1])[CH2:6][CH2:7]1참가 물질
6
반응 조건
- 온도
- 25 °C
실험 절차
2-(1,4-Dioxaspiro[4.5]dec-8-yl)ethanol (2.70 g, 0.0145 mol) was dissolved in acetone (10.00 mL) and THF (10.00 mL) and 6.00 M HCl (6.00 mL) was added. The reaction was stirred at 25° C. for 16 hours, neutralized with NaHCO3 solution and was then extracted with ethyl acetate. The organic extracts were washed with water, and with saturated NaCl, then dried (MgSO4) and concentrated in vacuo. The crude product was used in the next reaction without further purification. 1H NMR (CDCl3): 3.75 (m, 2H), 2.36 (m, 4H), 1.20-2.13 (m, 7H).
후처리
- extractionwas then extracted with ethyl acetate
- washThe organic extracts were washed with water
- dry with materialwith saturated NaCl, then dried (MgSO4)
- concentrationconcentrated in vacuo
- customThe crude product was used in the next reaction without further purification
출처 및 근거
- ORD 기록
- ord-febdcda125884427ad891da3ebe58e0e
- 출처 데이터셋
- uspto-grants-2013_09
- 특허 번호
- US08530485B2
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