Lithium hydroxide, monohydrate → 5-Phenylbenzo[b]thiophene-2-carboxylic acid

HRID 409897노트

반응식

HRID 409897 반응식
[C:1]1([C:7]2[CH:19]=[CH:18][C:10]3[S:11][C:12]([C:14]([O:16]C)=[O:15])=[CH:13][C:9]=3[CH:8]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.O[Li].O>C1COCC1.O>[C:1]1([C:7]2[CH:19]=[CH:18][C:10]3[S:11][C:12]([C:14]([OH:16])=[O:15])=[CH:13][C:9]=3[CH:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

참가 물질

4

반응물 2

HCID 168937Lithium hydroxide, monohydrateHCID 19007392Methyl 5-phenylbenzo[b]thiophene-2-carboxylate

생성물 1

HCID 596260715-Phenylbenzo[b]thiophene-2-carboxylic acid수율 99.1%

시약·촉매·용매 1

HCID 21881883Oxolane--water (1/1)용매

실험 절차

A solution of compound 10c (510 mg, 1.9 mmol) and LiOH.H2O (319 mg, 7.6 mmol) in THF/H2O (10/10 mL) was stirred at room temperature overnight. The resulting mixture was concentrated and diluted with water. The water layer was acidified with 1N aqueous HCl to pH˜4 and extracted with CH2Cl2. The organic solution was dried over Na2SO4 and concentrated to give 10d (479 mg), which was used in the next reaction without further purification. MS m/z (M+H+) 255.0.

후처리

  1. concentrationThe resulting mixture was concentrated
  2. additiondiluted with water
  3. extractionextracted with CH2Cl2
  4. dry with materialThe organic solution was dried over Na2SO4
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-8da277fb9036411caf8c0d4615339046
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08759533B2

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