Lithium hydroxide, monohydrate → 3-(4-fluorophenyl)-1H-indole-6-carboxylic acid
반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:16]3[C:11](=[CH:12][C:13]([C:17]([O:19]C)=[O:18])=[CH:14][CH:15]=3)[NH:10][CH:9]=2)=[CH:4][CH:3]=1.O[Li].O>C1COCC1.O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:16]3[C:11](=[CH:12][C:13]([C:17]([OH:19])=[O:18])=[CH:14][CH:15]=3)[NH:10][CH:9]=2)=[CH:6][CH:7]=1참가 물질
4
실험 절차
A solution of compound 11d (303 mg, 0.79 mmol), and LiOH.H2O (132.7 mg, 3.16 mmol) in THF/H2O (10 mL/10 mL) was stirred at 45° C. for 5 h. The resulting mixture was concentrated and diluted with water. The water layer was acidified with 1N aqueous HCl to pH˜4 and extracted with CH2Cl2. The organic solution was dried over Na2SO4 and concentrated to give 11e (249 mg). MS m/z (M+H+) 256.0.
후처리
- concentrationThe resulting mixture was concentrated
- additiondiluted with water
- extractionextracted with CH2Cl2
- dry with materialThe organic solution was dried over Na2SO4
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-590a9a0a31be4b9f86aac4444fe0a759
- 출처 데이터셋
- uspto-grants-2014_06
- 특허 번호
- US08759533B2
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