Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl indole-6-carboxylate → methyl 3-fluoro-1H-indole-6-carboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl indole-6-carboxylate | HCID 639844 | — |
| 반응물 | 1-Fluoro-2,4,6-trimethylpyridinium Trifluoromethanesulfonate [Fluorinating Reagent] | HCID 2724575 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | methyl 3-fluoro-1H-indole-6-carboxylate | HCID 59625843 | — |
반응 단계
A solution of methyl 1H-indole-6-carboxylate 20a (11.4 mmol, 2.0 g) and N-fluoro-2,4,6-trimethylpyridinium triflate (14.8 mmol, 4.3 g) in MeOH (100 mL) was heated at reflux for 18 h. The reaction mixture was concentrated and purified by flash column chromatography (silica gel, 15-20% EtOAc/hexanes) to give compound 20b as an off-white solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08759533B2 |
| 출처 데이터셋 | uspto-grants-2014_06 |
| ORD ID | ord-73b9c93dbb2d4175912811e925bef103 |
| 출처 메모 | uspto-grants-2014_06 |