Water → HCID 59625812, 화합물

HRID 409930노트

반응식

HRID 409930 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[NH:12][C:13]1[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=1)[C:5]([O:7][CH3:8])=[O:6].[CH:20](OC)(OC)OC.O>CN(C=O)C>[F:19][C:16]1[CH:17]=[CH:18][C:13]([N:12]2[C:11]3[CH:10]=[CH:9][C:4]([C:5]([O:7][CH3:8])=[O:6])=[CH:3][C:2]=3[N:1]=[CH:20]2)=[CH:14][CH:15]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 9005Trimethyl orthoformateHCID 59625705HCID 59625705, 화합물

생성물 1

HCID 59625812HCID 59625812, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of 27d (0.18 g, 0.693 mmol) and trimethyl orthoformate (0.7 mL, 6.39 mmol) in DMF (2 mL) was refluxed for 5 h and then cooled to room temperature. Water was added to the mixture. The resulting solid was filtered, washed, with water, and dried. The crude product 27e was used in the next reaction without purification. MS m/z (M+H+) 271.1.

후처리

  1. temperaturewas refluxed for 5 h
  2. filtrationThe resulting solid was filtered
  3. washwashed, with water
  4. customdried
  5. customThe crude product 27e was used in the next reaction without purification

출처 및 근거

ORD 기록
ord-e0b80af3d8b3457b9b9e24255fea7b1f
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08759533B2

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