[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]([NH:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][C:20]2[CH:25]=[CH:24][N:23]=[C:22]3[CH:26]=[C:27]([C:29]4[N:30]([CH3:40])[C:31]([CH2:34][NH:35][CH2:36][CH2:37][O:38][CH3:39])=[CH:32][N:33]=4)[S:28][C:21]=23)=[C:15]([F:41])[CH:14]=1)=[O:11].[C:42]([O:46][C:47]([NH:49][C@@H:50]([CH:54]([CH3:56])[CH3:55])[C:51](O)=[O:52])=[O:48])([CH3:45])([CH3:44])[CH3:43].CCN(C(C)C)C(C)C.CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F>CN(C=O)C.CCOC(C)=O>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10](=[O:11])[NH:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][C:20]2[CH:25]=[CH:24][N:23]=[C:22]3[CH:26]=[C:27]([C:29]4[N:30]([CH3:40])[C:31]([CH2:34][N:35]([CH2:36][CH2:37][O:38][CH3:39])[C:51](=[O:52])[C@@H:50]([NH:49][C:47](=[O:48])[O:46][C:42]([CH3:45])([CH3:44])[CH3:43])[CH:54]([CH3:56])[CH3:55])=[CH:32][N:33]=4)[S:28][C:21]=23)=[C:15]([F:41])[CH:14]=1To a solution of the compound 351 (280 mg, 0.481 mmol) in DMF (10 ml) was added (S)-2-(tert-butoxycarbonylamino)-3-methylbutanoic acid (209 mg, 2 eq, 0.961 mmol), iPr2NEt (0.252 ml, 3 eq, 0.1.442 mmol) and HATU (365 mg, 2 eq, 0.961 mmol) and the reaction mixture was stirred overnight. The reaction mixture was diluted with EtOAc and washed with water, saturated NAHCO3 solution then brine. The organic phase was collected, dried over Na2SO4, filtered then concentrated. Purification of the residue by column chromatography (eluent 20% MeOH in EtOAc) afforded the desired compound 352 as an off-white solid (200 mg, 53% yield). MS (m/z)=782.7 (M+H).
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