Sodium Hydroxide → 2-{2,6-Dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]phenylamino}-6-(2,2,2-trifluoroethoxy)-7-fluoro-1H-benzimidazole-5-carboxylic acid
반응식
C[O:2][C:3]([C:5]1[C:30]([O:31][CH2:32][C:33]([F:36])([F:35])[F:34])=[C:29]([F:37])[C:8]2[NH:9][C:10]([NH:12][C:13]3[C:18]([Cl:19])=[CH:17][CH:16]=[C:15]([CH2:20][NH:21][C:22](=[O:27])[C:23]([CH3:26])([CH3:25])[CH3:24])[C:14]=3[Cl:28])=[N:11][C:7]=2[CH:6]=1)=[O:4].[OH-].[Na+]>>[Cl:28][C:14]1[C:15]([CH2:20][NH:21][C:22](=[O:27])[C:23]([CH3:24])([CH3:26])[CH3:25])=[CH:16][CH:17]=[C:18]([Cl:19])[C:13]=1[NH:12][C:10]1[NH:9][C:8]2[C:29]([F:37])=[C:30]([O:31][CH2:32][C:33]([F:36])([F:35])[F:34])[C:5]([C:3]([OH:4])=[O:2])=[CH:6][C:7]=2[N:11]=1참가 물질
3
실험 절차
The subtitle compound is prepared from 2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2,2,2-trifluoroethoxy)-7-fluoro-1H-benzimidazole-5-carboxylic acid methyl ester and NaOH in analogy to example 28a.
출처 및 근거
- ORD 기록
- ord-5817f2d056a1418a8a2aff385fd939a3
- 출처 데이터셋
- uspto-grants-2014_06