Hydrochloric Acid → HCID 178481216, 화합물

HRID 410119노트

반응식

HRID 410119 반응식
[F:1][C:2]([F:46])([F:45])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10]([C:12]2[C:39]([O:40][CH2:41][CH:42]([F:44])[F:43])=[CH:38][C:15]3[N:16]([CH3:37])[C:17]([NH:19][C:20]4[C:25]([Cl:26])=[CH:24][CH:23]=[C:22]([CH2:27][NH:28]C(OC(C)(C)C)=O)[C:21]=4[Cl:36])=[N:18][C:14]=3[CH:13]=2)=[O:11])[CH2:5][CH2:4]1.Cl>C1COCC1>[F:45][C:2]([F:1])([F:46])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10]([C:12]2[C:39]([O:40][CH2:41][CH:42]([F:43])[F:44])=[CH:38][C:15]3[N:16]([CH3:37])[C:17]([NH:19][C:20]4[C:25]([Cl:26])=[CH:24][CH:23]=[C:22]([CH2:27][NH2:28])[C:21]=4[Cl:36])=[N:18][C:14]=3[CH:13]=2)=[O:11])[CH2:5][CH2:4]1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 178481223HCID 178481223, 화합물

생성물 1

HCID 178481216HCID 178481216, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A mixture of N-(trans-4-trifluoromethyl-cyclohex-1-yl)-2-{2,6-dichloro-3-[(tert-butoxy-carbonylamino)-methyl]-phenylamino}-6-(2,2-difluoroethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid amide (350 mg, 0.504 mmol), 6 M aq. HCl-solution (15 mL) and THF (15 mL) is stirred overnight, the mixture is concentrated and directly used in the next step.

후처리

  1. concentrationthe mixture is concentrated

출처 및 근거

ORD 기록
ord-fb497aecdfeb47c3b50b0f5dc407db5f
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08759537B2

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