Cesium carbonate → [1-(2-(4-Biphenyl-2-ylmethyl-piperazin-1-yl)-benzyl]-3-[3-(4-fluoro-phenoxy)-propyl]-1,3-dihydro-benzoimidazol-ylidene]-carbamic acid tert-butyl ester

반응식

[C:1]([O:5][C:6](=[O:36])[N:7]=[C:8]1[N:12]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2Br)[C:11]2[CH:21]=[CH:22][CH:23]=[CH:24][C:10]=2[N:9]1[CH2:25][CH2:26][CH2:27][O:28][C:29]1[CH:34]=[CH:33][C:32]([F:35])=[CH:31][CH:30]=1)([CH3:4])([CH3:3])[CH3:2].[C:37]1([C:50]2[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=2)[CH:42]=[CH:41][CH:40]=[CH:39][C:38]=1[CH2:43][N:44]1[CH2:49][CH2:48][NH:47][CH2:46][CH2:45]1.C([O-])([O-])=O.[Cs+].[Cs+]>C1(C)C=CC=CC=1.CC([O-])=O.CC([O-])=O.[Pd+2]>[C:1]([O:5][C:6](=[O:36])[N:7]=[C:8]1[N:12]([CH2:13][C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=2[N:47]2[CH2:48][CH2:49][N:44]([CH2:43][C:38]3[CH:39]=[CH:40][CH:41]=[CH:42][C:37]=3[C:50]3[CH:55]=[CH:54][CH:53]=[CH:52][CH:51]=3)[CH2:45][CH2:46]2)[C:11]2[CH:21]=[CH:22][CH:23]=[CH:24][C:10]=2[N:9]1[CH2:25][CH2:26][CH2:27][O:28][C:29]1[CH:34]=[CH:33][C:32]([F:35])=[CH:31][CH:30]=1)([CH3:4])([CH3:3])[CH3:2]