6-Fluoroindole → Sodium 6-Fluoro-1H-indole-2-sulfonate

HRID 41066

반응식

HRID 41066 반응식
[S:1](=[O:4])([OH:3])[O-:2].[Na+:5].[F:6][C:7]1[CH:15]=[C:14]2[C:10]([CH:11]=[CH:12][NH:13]2)=[CH:9][CH:8]=1>O.C(O)C>[F:6][C:7]1[CH:15]=[C:14]2[C:10]([CH:11]=[C:12]([S:1]([O-:3])(=[O:2])=[O:4])[NH:13]2)=[CH:9][CH:8]=1.[Na+:5]

참가 물질

5

반응물 2

HCID 3512786-FluoroindoleHCID 23665763Sodium Bisulfite

생성물 1

HCID 86634332Sodium 6-Fluoro-1H-indole-2-sulfonate수율 29.5%

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

To a solution of 23.4 g sodium bisulfite in 80 ml water a solution of 13.5 g 6-fluoro indole in ethanol is added drop wise. The obtained suspension is stirred at room temperature over night. The precipitate is filtered and washed with cold water, cold methanol and diethyl ether. 7.0 g (29%) of the title compound are obtained as a colourless solid.

후처리

  1. filtrationThe precipitate is filtered
  2. washwashed with cold water, cold methanol and diethyl ether

출처 및 근거

ORD 기록
ord-524347121123467c90bcf38b3fc5d8c2
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08530493B2

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