Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,1'-Thiocarbonyldiimidazole → 2-(6-Methanesulfonyl-benzothiazol-2-ylamino)-1-methyl-1H-benzoimidazole-5-carboxylic acid methyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,1'-Thiocarbonyldiimidazole | HCID 80264 | — |
| 반응물 | 2-Benzothiazolamine, 6-(methylsulfonyl)- | HCID 87152 | — |
| 반응물 | Methyl 3-amino-4-(methylamino)benzoate | HCID 15586064 | — |
| 용매 | 1,2-Dichloroethane | HCID 11 | — |
| 생성물 | 2-(6-Methanesulfonyl-benzothiazol-2-ylamino)-1-methyl-1H-benzoimidazole-5-carboxylic acid methyl ester | HCID 58397583 | 78.9% |
반응 단계
2-(6-Methanesulfonyl-benzothiazol-2-ylamino)-1-methyl-1H-benzoimidazole-5-carboxylic acid methyl ester (1.64 g) was prepared by following General Procedure D starting from 3-amino-4-methylamino-benzoic acid methyl ester (0.9 g), 2-amino-6-methanesulfonyl-benzothiazole (1.14 g), 1,1′-thiocarbonyldiimidazole (1.07 g), and EDC (1.15 g). LC/MS: m/z 418.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08759535B2 |
| 출처 데이터셋 | uspto-grants-2014_06 |
| ORD ID | ord-ce39c1b176cc4314aaf33a9cce5cd659 |
| 출처 메모 | uspto-grants-2014_06 |