Sodium Hydroxide → 3-Methyl-2-(6-trifluoromethoxy-benzothiazol-2-ylamino)-3H-benzoimidazole-5-carboxylic acid

HRID 411003노트

반응식

HRID 411003 반응식
C([O:3][C:4]([C:6]1[CH:30]=[CH:29][C:9]2[N:10]=[C:11]([NH:14][C:15]3[S:16][C:17]4[CH:23]=[C:22]([O:24][C:25]([F:28])([F:27])[F:26])[CH:21]=[CH:20][C:18]=4[N:19]=3)[N:12]([CH3:13])[C:8]=2[CH:7]=1)=[O:5])C.[OH-].[Na+]>CO.C1COCC1>[CH3:13][N:12]1[C:8]2[CH:7]=[C:6]([C:4]([OH:5])=[O:3])[CH:30]=[CH:29][C:9]=2[N:10]=[C:11]1[NH:14][C:15]1[S:16][C:17]2[CH:23]=[C:22]([O:24][C:25]([F:27])([F:26])[F:28])[CH:21]=[CH:20][C:18]=2[N:19]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 866569143-Methyl-2-(6-trifluoromethoxy-benzothiazol-2-ylamino)-3H-benzoimidazole-5-carboxylic acid ethyl ester

생성물 1

HCID 866569153-Methyl-2-(6-trifluoromethoxy-benzothiazol-2-ylamino)-3H-benzoimidazole-5-carboxylic acid수율 95.4%

시약·촉매·용매 1

HCID 21899815MeOH tetrahydrofuran용매

실험 절차

3-Methyl-2-(6-trifluoromethoxy-benzothiazol-2-ylamino)-3H-benzoimidazole-5-carboxylic acid (2.5 g) was prepared by following General Procedure E starting from 3-methyl-2-(6-trifluoromethoxy-benzothiazol-2-ylamino)-3H-benzoimidazole-5-carboxylic acid ethyl ester (2.8 g) and 2 N NaOH (6 mL) in methanol:THF (1:1, 12 mL).

출처 및 근거

ORD 기록
ord-f6efeb5a50b247e489107f1ea47f8347
출처 데이터셋
uspto-grants-2014_06
특허 번호
US08759535B2

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