4-Bromo-3-phenyl-1H-pyrazol-5-amine → 3-[[(4-bromo-5-phenyl-1H-pyrazol-3-yl)amino]methylidene]-4-methyl-1H-indol-2-one

HRID 411675

반응식

HRID 411675 반응식
O/[CH:2]=[C:3]1\[C:4](=[O:13])[NH:5][C:6]2[C:11]\1=[C:10]([CH3:12])[CH:9]=[CH:8][CH:7]=2.O/C=C1\C(=O)NC2C\1=CC=CC=2.[Br:26][C:27]1[C:28]([NH2:38])=[N:29][NH:30][C:31]=1[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1.NC1C=CNN=1>O1CCCC1>[Br:26][C:27]1[C:28]([NH:38][CH:2]=[C:3]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][C:10]=3[CH3:12])[NH:5][C:4]2=[O:13])=[N:29][NH:30][C:31]=1[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1

참가 물질

6

반응물 4

HCID 5943194-Bromo-3-phenyl-1H-pyrazol-5-amine2회HCID 178418806HCID 178418806, 화합물HCID 178423596HCID 178423596, 화합물2회HCID 178517101HCID 178517101, 화합물

생성물 1

HCID 1784235953-[[(4-bromo-5-phenyl-1H-pyrazol-3-yl)amino]methylidene]-4-methyl-1H-indol-2-one

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

The named compound is prepared by substituting E & Z-3-[(hydroxy)-methylene]-4-methyl-1,3-dihydro-indol-2-one for E & Z-3-[(hydroxy)-methylene]-1,3-dihydro-indol-2-one and 4-bromo-5-phenyl-1H-pyrazol-3-ylamine for 3-aminopyrazole in the reaction of Example 1. Specifically, E & Z-3-[(hydroxy)-methylene]-4-methyl-1,3-dihydro-indol-2-one (0.1622 gms.) is reacted with 0.4530 gms. of 4-bromo-5-phenyl-1H-pyrazol-3-ylamine by refluxing in tetrahydrofuran (3.0 mL).

후처리

  1. customThe named compound is prepared
  2. customin the reaction of Example 1

출처 및 근거

ORD 기록
ord-60f37002e36a4a62a973846351568cc2
출처 데이터셋
uspto-grants-2003_05
특허 번호
US06559173B1

연결된 노트

불러오는 중…