Chlorotrimethylsilane → Methyl 2,2,4-Trimethyl-3-silyloxypent-3-enecarboxylate

HRID 411887

반응식

HRID 411887 반응식
[CH3:1][C:2]1([CH3:10])[C:5](=O)[C:4]([CH3:8])([CH3:7])[C:3]1=[O:9].[CH3:11][O-:12].[Na+].C[Si:15](Cl)(C)C.[O:19]1[CH2:23]CCC1>>[CH3:10][C:2]([CH3:1])([C:3]([O:9][SiH3:15])=[C:4]([CH3:7])[CH3:8])[CH2:5][C:11]([O:19][CH3:23])=[O:12]

참가 물질

5

반응물 4

HCID 6397ChlorotrimethylsilaneHCID 8028TetrahydrofuranHCID 136172,2,4,4-Tetramethyl-1,3-cyclobutanedioneHCID 10942334Sodium Methoxide

생성물 1

HCID 123759875Methyl 2,2,4-Trimethyl-3-silyloxypent-3-enecarboxylate

실험 절차

84 g (0.6 mol) of 2,2,4,4-tetramethylcyclobutane-1,3-dione and 32.4 g (0.6 mol) of sodium methylate were mixed together in 320 ml of tetrahydrofuran. 65.1 g (0.6 mol) of trimethylsilyl chloride were added dropwise and the mixture was stirred. The reaction mixture was then concentrated and the residue was taken up with diethyl ether. The solid was filtered off with suction and the mother liquor was concentrated. Yield: 135 g (89%).

후처리

  1. concentrationThe reaction mixture was then concentrated
  2. filtrationThe solid was filtered off with suction
  3. concentrationthe mother liquor was concentrated

출처 및 근거

ORD 기록
ord-018233e2db2a44b78cd771c96c80a5be
출처 데이터셋
uspto-grants-2003_05
특허 번호
US06559343B1

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