Benzene, 1-iodo-4-(trifluoromethyl)- → 4-(4-Trifluoromethylphenyl)-thiomorpholin-3-one

HRID 411988

반응식

HRID 411988 반응식
[NH:1]1[CH2:6][CH2:5][S:4][CH2:3][C:2]1=[O:7].[F:8][C:9]([F:18])([F:17])[C:10]1[CH:15]=[CH:14][C:13](I)=[CH:12][CH:11]=1>[Cu]>[F:8][C:9]([F:18])([F:17])[C:10]1[CH:15]=[CH:14][C:13]([N:1]2[CH2:6][CH2:5][S:4][CH2:3][C:2]2=[O:7])=[CH:12][CH:11]=1

참가 물질

4

반응물 2

HCID 67993Benzene, 1-iodo-4-(trifluoromethyl)-HCID 884021,4-Tetrahydrothiazine-3-one

생성물 1

HCID 120830104-(4-Trifluoromethylphenyl)-thiomorpholin-3-one수율 23.3%

시약·촉매·용매 1

HCID 23978Copper촉매

반응 조건

온도
192.5 °C

실험 절차

A mixture of thiomorpholin-3-one (500 mg, 4.27 mmol), 4-trifluoromethyl-1-iodobenzene (1.25 mL, 8.5 mmol) and copper metal (814 mg, 12.8 mmol) was heated in a sealed glass tube at 185-200° C. for 18 hours. The residue was then purified by flash chromatography to give 260 mg of the title product as a white solid.

후처리

  1. customThe residue was then purified by flash chromatography

출처 및 근거

ORD 기록
ord-ad8e8f21d3844c8da18ab3779257a5e3
출처 데이터셋
uspto-grants-2003_05
특허 번호
US06562813B2

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