Diisopropylethylamine → n-[7-((Methanesulfonyl)oxy)naphthyl]-2-[n'-(2-(1-triphenylmethyl-4-imidazolyl)ethyl)amino]acetamide

HRID 412171노트

반응식

HRID 412171 반응식
[C:1]1([C:7]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[N:8]2[CH:12]=[C:11]([CH2:13][CH2:14][NH2:15])[N:10]=[CH:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C(N(C(C)C)CC)(C)C.Cl[CH2:38][C:39]([NH:41][C:42]1[C:51]2[C:46](=[CH:47][CH:48]=[C:49]([O:52][S:53]([CH3:56])(=[O:55])=[O:54])[CH:50]=2)[CH:45]=[CH:44][CH:43]=1)=[O:40]>C(#N)C>[CH3:56][S:53]([O:52][C:49]1[CH:50]=[C:51]2[C:46]([CH:45]=[CH:44][CH:43]=[C:42]2[NH:41][C:39](=[O:40])[CH2:38][NH:15][CH2:14][CH2:13][C:11]2[N:10]=[CH:9][N:8]([C:7]([C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)([C:16]3[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=3)[C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)[CH:12]=2)=[CH:47][CH:48]=1)(=[O:55])=[O:54]

참가 물질

5

반응물 3

HCID 81531DiisopropylethylamineHCID 6183402-(1-Trityl-1H-imidazol-4-yl)-ethylamineHCID 155493251-(Chloroacetamido)-7-[(methanesulfonyl)oxy]naphthalene

생성물 1

HCID 18536022n-[7-((Methanesulfonyl)oxy)naphthyl]-2-[n'-(2-(1-triphenylmethyl-4-imidazolyl)ethyl)amino]acetamide

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

To a solution of the product from Step B (25.6 g, 72.7 mmol) in 200 mL of acetonitrile was added diisopropylethylamine (50 mL, 303 mmol), followed by the product from Step D (19.0 g, 60.5 mmol). The reaction was stirred at room temperature overnight, then concentrated in vacuo. The resulting material was partitioned between EtOAc and water, washed with brine, dried (MgSO4), filtered, and concentrated in vacuo to provide the titled product.

후처리

  1. concentrationconcentrated in vacuo
  2. customThe resulting material was partitioned between EtOAc and water
  3. washwashed with brine
  4. dry with materialdried (MgSO4)
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-7f4b809b1d22411c9cb661d6ae3361f0
출처 데이터셋
uspto-grants-2003_05
특허 번호
US06562823B1

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