3-Chlorobenzaldehyde → 2-m-Chlorophenyl-3-(3-trifluoromethyl-4-fluorophenyl)-5-ethyl oxazolidine

HRID 4122

반응식

HRID 4122 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[CH:5]=[O:6].[F:10][C:11]([F:26])([F:25])[C:12]1[CH:13]=[C:14]([NH:19][CH2:20][CH:21](O)[CH2:22][CH3:23])[CH:15]=[CH:16][C:17]=1[F:18]>CS(O)(=O)=O>[Cl:1][C:2]1[CH:3]=[C:4]([CH:5]2[N:19]([C:14]3[CH:15]=[CH:16][C:17]([F:18])=[C:12]([C:11]([F:26])([F:10])[F:25])[CH:13]=3)[CH2:20][CH:21]([CH2:22][CH3:23])[O:6]2)[CH:7]=[CH:8][CH:9]=1

참가 물질

4

반응물 2

HCID 114773-ChlorobenzaldehydeHCID 201526711-(3-Trifluoromethyl-4-fluorophenylamino)-2-butanol

생성물 1

HCID 201526702-m-Chlorophenyl-3-(3-trifluoromethyl-4-fluorophenyl)-5-ethyl oxazolidine

시약·촉매·용매 1

HCID 6395Methanesulfonic Acid촉매

실험 절차

Meta-chlorobenzaldehyde (2.3 g, 0.016 mole) was combined with 5 g of 1-(3-trifluoromethyl-4-fluorophenylamino)-2-butanol and 3 drops of methane sulfonic acid was added. The mixture was heated on the steam bath for about one hour and stripped on the rotary evaporator. The product, a sticky, thick liquid, was characterized by IR and NMR.

후처리

  1. additionwas added
  2. temperatureThe mixture was heated on the steam bath for about one hour
  3. customstripped on the rotary evaporator

출처 및 근거

ORD 기록
ord-2606b9cbf440416d8f3e63a1500dbed7
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04723986

연결된 노트

불러오는 중…