Hydrochloric Acid → Efatutazone Dihydrochloride
반응식
[NH2:1][C:2]1[C:34]([CH3:35])=[CH:33][C:5]([O:6][C:7]2[CH:8]=[CH:9][C:10]3[N:14]=[C:13]([CH2:15][O:16][C:17]4[CH:30]=[CH:29][C:20]([CH2:21][CH:22]5[S:26][C:25](=[O:27])[NH:24][C:23]5=[O:28])=[CH:19][CH:18]=4)[N:12]([CH3:31])[C:11]=3[CH:32]=2)=[CH:4][C:3]=1[CH3:36].[ClH:37]>C(OCC)(=O)C>[ClH:37].[ClH:37].[NH2:1][C:2]1[C:3]([CH3:36])=[CH:4][C:5]([O:6][C:7]2[CH:8]=[CH:9][C:10]3[N:14]=[C:13]([CH2:15][O:16][C:17]4[CH:18]=[CH:19][C:20]([CH2:21][CH:22]5[S:26][C:25](=[O:27])[NH:24][C:23]5=[O:28])=[CH:29][CH:30]=4)[N:12]([CH3:31])[C:11]=3[CH:32]=2)=[CH:33][C:34]=1[CH3:35]참가 물질
4
실험 절차
A mixture of 5-[4-[6-(4-amino-3 ,5-dimethylphenoxy)-1-methyl-1H-benzimidazol-2-ylmethoxy]benzyl]thiazolidine-2,4-dione (0.25 g) and 4N hydrogen chloride in ethyl acetate (50 ml) was stirred at room temperature for 24 hours. The insoluble product was filtered and washed with ethyl acetate to afford the desired product (0.25 g, mp 165-175° C.).
후처리
- filtrationThe insoluble product was filtered