Sodium Hydroxide → 1-Methylsulfonyl-2-trifluoromethoxybenzene
반응식
[CH3:1][S:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[O:9][C:10]([F:13])([F:12])[F:11].ClC1C=C(C=CC=1)C(OO)=[O:19].[OH-:25].[Na+]>C(Cl)Cl>[CH3:1][S:2]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[O:9][C:10]([F:11])([F:12])[F:13])(=[O:19])=[O:25]참가 물질
5
실험 절차
1-Methylsulfanyl-2-trifluoromethoxybenzene (15.0 g, 72 mmol) was dissolved in DCM (200 mL) and m-chloroperoxybenzoic acid (39.0 g, 216 mmol) was added in small portions during 30 min. The reaction mixture was then allowed to stand overnight. DCM (200 mL) was added followed by slow addition of sodium hydroxide (2 N, 200 mL). The organic phase was separated and washed with sodium hydroxide (2 N, 3×150 mL), dried (magnesium sulphate) and concentrated in vacuo to give 15.8 g of 1-methylsulfonyl-2-trifluoromethoxybenzene
후처리
- customThe organic phase was separated
- washwashed with sodium hydroxide (2 N, 3×150 mL)
- dry with materialdried (magnesium sulphate)
- concentrationconcentrated in vacuo
출처 및 근거
- ORD 기록
- ord-5d273f08cc454ed69cb6e31b965c5158
- 출처 데이터셋
- uspto-grants-2003_05
- 특허 번호
- US06562807B2
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