Hydrogen Bromide → 1,2,3,4-Tetrahydroisoquinolin-6-ol hydrobromide

반응식

C[O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH2:9][NH:8][CH2:7][CH2:6]2.[BrH:13]>>[BrH:13].[OH:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH2:9][NH:8][CH2:7][CH2:6]2

참가 물질

반응물 2

HCID 260Hydrogen Bromide

HCID 393566-Methoxy-1,2,3,4-tetrahydroisoquinoline

생성물 1

HCID 133617991,2,3,4-Tetrahydroisoquinolin-6-ol hydrobromide

실험 절차

6-Methoxy-1,2,3,4-tetrahydroisoquinoline (2.89 g) was dissolved in 48% aqueous hydrogen bromide solution (70 ml) and the mixture was refluxed for 2 hours. The solvent was evaporated and to the obtained residue were added ethanol and diethyl ether. The mixture was filtrated and dried under reduced pressure to give the title compound (3.93 g).

후처리

temperaturethe mixture was refluxed for 2 hours
customThe solvent was evaporated and to the obtained residue
additionwere added ethanol and diethyl ether
filtrationThe mixture was filtrated
customdried under reduced pressure

출처 및 근거

ORD 기록: ord-45378efb71f6493387a5248cd1d3c7af
출처 데이터셋: uspto-grants-2003_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06562828B1

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