Hydrogen Bromide → 2,3,4,5-tetrahydro-1H-2-benzazepin-8-ol hydrobromide

HRID 412595노트

반응식

HRID 412595 반응식
C[O:2][C:3]1[CH:4]=[CH:5][C:6]2[CH2:12][CH2:11][CH2:10][NH:9][CH2:8][C:7]=2[CH:13]=1.[BrH:14]>>[BrH:14].[OH:2][C:3]1[CH:4]=[CH:5][C:6]2[CH2:12][CH2:11][CH2:10][NH:9][CH2:8][C:7]=2[CH:13]=1

참가 물질

3

반응물 2

HCID 260Hydrogen BromideHCID 154969548-Methoxy-2,3,4,5-tetrahydro-1H-benzo(c)azepine

생성물 1

HCID 114479102,3,4,5-tetrahydro-1H-2-benzazepin-8-ol hydrobromide

실험 절차

8-Methoxy-2,3,4,5-tetrahydro-1H-benz[c]azepine (3.65 g) was dissolved in 48% aqueous hydrogen bromide solution (36 ml) and the mixture was refluxed for 2 hours. The solvent was evaporated and ethanol and diethyl ether were added to the obtained residue. The mixture was filtrated and dried under reduced pressure to give the title compound (4.56 g).

후처리

  1. temperaturethe mixture was refluxed for 2 hours
  2. customThe solvent was evaporated
  3. additionethanol and diethyl ether were added to the obtained residue
  4. filtrationThe mixture was filtrated
  5. customdried under reduced pressure

출처 및 근거

ORD 기록
ord-949b71e773254f5188db2f623d3f8843
출처 데이터셋
uspto-grants-2003_05
특허 번호
US06562828B1

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