Hydrochloric Acid → 6-Bromo-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]pyrazolo[5,1-b][1,3]thiazole

HRID 41267

반응식

HRID 41267 반응식
[Br:1][C:2]1[C:22](C(O)=O)=[C:5]2[S:6][CH:7]=[C:8]([C:9]3[C:14]([O:15][CH3:16])=[CH:13][C:12]([CH2:17][O:18][CH3:19])=[CH:11][C:10]=3[O:20][CH3:21])[N:4]2[N:3]=1.Cl>O1CCOCC1>[Br:1][C:2]1[CH:22]=[C:5]2[S:6][CH:7]=[C:8]([C:9]3[C:10]([O:20][CH3:21])=[CH:11][C:12]([CH2:17][O:18][CH3:19])=[CH:13][C:14]=3[O:15][CH3:16])[N:4]2[N:3]=1

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 58223485HCID 58223485, 화합물

생성물 1

HCID 582234186-Bromo-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]pyrazolo[5,1-b][1,3]thiazole수율 25%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

To a 1,4-dioxane (90.0 mL) solution of 6-bromo-3-[2,6-dimethoxy-4-(methoxymethyl)phenyl]pyrazolo[5,1-b][1,3]thiazole-7-carboxylic acid (5.00 g, 11.7 mmol) was added concentrated hydrochloric acid (14.9 mL) and the mixture was heated to reflux for 13 hours. After the reaction was completed, the solvent was distilled off under reduced pressure, water (50 mL) was added to the residue, and the precipitated solid was subjected to suction filtration and dried to obtain the title compound (1.12 g, 2.92 mmol).

후처리

  1. temperaturethe mixture was heated
  2. temperatureto reflux for 13 hours
  3. distillationthe solvent was distilled off under reduced pressure, water (50 mL)
  4. additionwas added to the residue
  5. filtrationthe precipitated solid was subjected to suction filtration
  6. customdried

출처 및 근거

ORD 기록
ord-7e5e6bca274745aa8f6228e6e192d79a
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08530504B2

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