2-Bromotoluene → 2,2'-Dimethylbiphenyl

HRID 412819

반응식

HRID 412819 반응식
Br[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH3:8].[CH3:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1B(O)O.[F-].[K+]>C1COCC1>[CH3:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=1[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH3:8]

참가 물질

5

반응물 3

HCID 72362-BromotolueneHCID 522689Potassium FluorideHCID 27332672-Methylphenyl boronic acid

생성물 1

HCID 117972,2'-Dimethylbiphenyl수율 98%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

2-Bromotoluene (87 mg, 0.51 mmol) reacted with 2-methylphenylboronic acid (88 mg, 0.65 mmol) using 1 mol % of Pd(dba)2/Ph5FcP(t-Bu)2 and KF (87 mg, 1.50 mmol) in THF solvent at room temperature to give the title compound (91 mg, 98%) as a colorless oil: 1H-NMR (300 MHz, CDCl3): δ 7.29-7.35 (m, 6H), 7.20 (d, 2H, J=6.3 Hz), 2.15 (s, 6H).). 13C{1H}-NMR (100 MHz, CDCl3): δ 141.56, 135.76, 129.77, 129.25, 127.12, 125.51, 19.81. GC/MS(EI): m/z 182 (M+).

후처리

  1. customat room temperature

출처 및 근거

ORD 기록
ord-40b553aec2194ce18bed40f417ad18bc
출처 데이터셋
uspto-grants-2003_05
특허 번호
US06562989B2

연결된 노트

불러오는 중…