Glycolide → HCID 178465153, 화합물

HRID 412991

반응식

HRID 412991 반응식
C1OC(=O)COC1=O.[CH3:9][CH2:10][NH:11][C:12]([C@H:14]1[N:18]([C:19]([C@@H:21]([NH:29][C:30]([C@@H:32]([NH:37][C:38]([C@H:40]([NH:45][C:46]([C@@H:48]([NH:57][C:58]([C@@H:60]([NH:63][C:64]([C@@H:66]([NH:77][C:78]([C@@H:80]([NH:87][C:88]([C@H:90]2[NH:95][C:93](=[O:94])[CH2:92][CH2:91]2)=[O:89])[CH2:81][C:82]2[N:86]=[CH:85][NH:84][CH:83]=2)=[O:79])[CH2:67][C:68]2[C:72]3[CH:73]=[CH:74][CH:75]=[CH:76][C:71]=3[NH:70][CH:69]=2)=[O:65])[CH2:61][OH:62])=[O:59])[CH2:49][C:50]2[CH:51]=[CH:52][C:53]([OH:56])=[CH:54][CH:55]=2)=[O:47])[CH2:41][CH:42]([CH3:44])[CH3:43])=[O:39])[CH2:33][CH:34]([CH3:36])[CH3:35])=[O:31])[CH2:22][CH2:23][CH2:24][NH:25][C:26]([NH2:28])=[NH:27])=[O:20])[CH2:17][CH2:16][CH2:15]1)=[O:13].CC(O)=O>CN1C(=O)CCC1.O>[CH3:9][CH2:10][NH:11][C:12]([C@H:14]1[N:18]([C:19]([C@@H:21]([NH:29][C:30]([C@@H:32]([NH:37][C:38]([C@H:40]([NH:45][C:46]([C@@H:48]([NH:57][C:58]([C@@H:60]([NH:63][C:64]([C@@H:66]([NH:77][C:78]([C@@H:80]([NH:87][C:88]([C@H:90]2[NH:95][C:93](=[O:94])[CH2:92][CH2:91]2)=[O:89])[CH2:81][C:82]2[N:86]=[CH:85][NH:84][CH:83]=2)=[O:79])[CH2:67][C:68]2[C:72]3[CH:73]=[CH:74][CH:75]=[CH:76][C:71]=3[NH:70][CH:69]=2)=[O:65])[CH2:61][OH:62])=[O:59])[CH2:49][C:50]2[CH:55]=[CH:54][C:53]([OH:56])=[CH:52][CH:51]=2)=[O:47])[CH2:41][CH:42]([CH3:44])[CH3:43])=[O:39])[CH2:33][CH:34]([CH3:36])[CH3:35])=[O:31])[CH2:22][CH2:23][CH2:24][NH:25][C:26]([NH2:28])=[NH:27])=[O:20])[CH2:17][CH2:16][CH2:15]1)=[O:13]

참가 물질

6

반응물 3

HCID 65432GlycolideHCID 178435178HCID 178435178, 화합물HCID 178476396HCID 178476396, 화합물

생성물 1

HCID 178465153HCID 178465153, 화합물

시약·촉매·용매 2

HCID 962Water용매HCID 13387N-methyl-2-pyrrolidone용매

실험 절차

Poly(DL-lactide-co-glycolide) with a molar ratio of lactide to glycolide of 75/25 (Birmingham Polymer, Inc.) was dissolved in NMP to give a solution with 45% by weight polymer. This solution was filled into 3.0 cc polyproylene syringes with a male luer lock fitting and terminally sterilized by exposure to gamma irradiation at 23.2-24.6 kilograys. The polymer molecular weight after irradiation was 15,094 daltons. Leuprolide acetate was dissolved in water, sterile filtered through 0.2 mm filter and filled into a polypropylene syringe with a male luer lock fitting. The aqueous solution was frozen and the water removed by vacuum to yield a lyophilized cake of leuprolide. The two syringes were connected together with a coupler immediately prior to use and the contents of the two syringes mixed by moving the material back and forth between the two syringes for 40 cycles to provide a formulation with 6% by weight of leuprolide acetate. The product was then pulled into the syringe with the male luer lock fitting one a one-half inch 20 gauge needle attached.

후처리

  1. customto give a solution with 45% by weight polymer
  2. customterminally sterilized by exposure to gamma irradiation at 23.2-24.6 kilograys
  3. customThe polymer molecular weight after irradiation
  4. filtrationsterile filtered through 0.2 mm
  5. filtrationfilter
  6. additionfilled into a polypropylene syringe with a male luer lock
  7. temperatureThe aqueous solution was frozen
  8. customthe water removed by vacuum

출처 및 근거

ORD 기록
ord-99951c4a067a46c7b16d996c7f586156
출처 데이터셋
uspto-grants-2003_05
특허 번호
US06565874B1

연결된 노트

불러오는 중…