Water → 1,1'-(1-Bromoethane-1,2-diyl)dibenzene

HRID 41321

반응식

HRID 41321 반응식
[C:1]1([CH:7](O)[CH2:8][C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.P(Br)(Br)[Br:17].O>C(OCC)C>[Br:17][CH:7]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

참가 물질

5

반응물 3

HCID 962WaterHCID 24614Phosphorus tribromideHCID 941781,2-Diphenylethanol

생성물 1

HCID 124997111,1'-(1-Bromoethane-1,2-diyl)dibenzene수율 84%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

반응 조건

온도
-10 °C

실험 절차

To a solution of 12.0 (60.5 mmol) of 1,2-diphenylethanol in 50 mL of dry diethyl ether, 11.0 g (3.80 mL, 40.0 mmol) of PBr3 was added with vigorous stirring at −10° C. The resulting mixture was stirred for 12 hr at room temperature and then added to 350 mL of cold water. The organic layer was separated, and the aqueous layer was extracted with 2×100 mL of water. The combined organic extracts were washed with aqueous NaHCO3, dried over Na2SO4, and evaporated to dryness. This procedure gave 13.2 g (84%) of the title product.

후처리

  1. stirringThe resulting mixture was stirred for 12 hr at room temperature
  2. customThe organic layer was separated
  3. extractionthe aqueous layer was extracted with 2×100 mL of water
  4. washThe combined organic extracts were washed with aqueous NaHCO3
  5. dry with materialdried over Na2SO4
  6. customevaporated to dryness

출처 및 근거

ORD 기록
ord-955a6e2a0d374c7495f12d087392dfcb
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08530593B2

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