Sodium hydride → 2-(2-Chloroethyl)-5-phenyl-1,2,5-thiadiazolidine-1,1-dioxide
반응식
[Cl:1][CH2:2][CH2:3][N:4]([CH2:15][CH2:16]Cl)[S:5]([NH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)(=[O:7])=[O:6].[H-].[Na+]>CN(C=O)C>[Cl:1][CH2:2][CH2:3][N:4]1[CH2:15][CH2:16][N:8]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[S:5]1(=[O:7])=[O:6]참가 물질
4
실험 절차
Using a slow dropper, a solution of 12.6 g of the product obtained in Step 2 above in 25 ml of DMF is introduced onto a suspension of 1.4 g of NaH in 175 ml of DMF and stirring is carried out for 12 hours. The reaction mixture is then poured onto ice in order to bring about crystallisation of the expected product.
후처리
- additionThe reaction mixture is then poured onto ice in order
- customto bring about crystallisation of the expected product
출처 및 근거
- ORD 기록
- ord-7fc9ec499689454980b9669c39b87220
- 출처 데이터셋
- uspto-grants-2003_05
- 특허 번호
- US06566364B2
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