Sodium borohydride → (2-Chloro-5-methylpyridin-3-yl)methanol

HRID 413477노트

반응식

[Cl:1][C:2]1[C:7]([CH:8]=[O:9])=[CH:6][C:5]([CH3:10])=[CH:4][N:3]=1.[BH4-].[Na+]>>[Cl:1][C:2]1[C:7]([CH2:8][OH:9])=[CH:6][C:5]([CH3:10])=[CH:4][N:3]=1

참가 물질

반응물 2

HCID 4311764Sodium borohydride

HCID 98340182-Chloro-5-methylpyridine-3-carbaldehyde

생성물 1

HCID 12056721(2-Chloro-5-methylpyridin-3-yl)methanol

실험 절차

comprising reducing 2-chloro-5-methylpyridine-3-carbaldehyde with sodium borohydride to give 2-chloro-3-hydroxymethyl-5-methylpyridine, followed by reacting the 2-chloro-3-hydroxymethyl-5-methylpyridine thus obtained with thionyl chloride to give 2-chloro-3-chloromethyl-5-methylpyridine, followed by reacting the 2-chloro-3-chloromethyl-5-methylpyridine thus obtained with 2-nitroimino-1,3-diazacyclopentane in the presence of a base and an organic solvent, to give 1-(2-chloro-5-methyl-3-pyridylmethyl)-2-nitroiminoimidazolidine.

출처 및 근거

ORD 기록: ord-b897a3831f2d4654aa74c2acd25446d6
출처 데이터셋: uspto-grants-2003_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US06566528B1

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