Hydrochloric Acid → 2-Methyl-4-aminobiphenyl hydrochloride

HRID 413497노트

반응식

HRID 413497 반응식
O.[ClH:2].[CH3:3][C:4]1[CH:9]=[C:8]([NH:10]C(C)=O)[CH:7]=[CH:6][C:5]=1[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>C(O)(=O)C>[ClH:2].[CH3:3][C:4]1[CH:9]=[C:8]([NH2:10])[CH:7]=[CH:6][C:5]=1[C:14]1[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=1

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 111721562-Methyl-4-acetaminobiphenyl

생성물 1

HCID 185334912-Methyl-4-aminobiphenyl hydrochloride

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

300 g of water and 296 g of HCl (37%) are added to the 2-methyl-4-acetaminobiphenyl prepared as described in Example 1. Any chlorobenzene still present is distilled off azeotropically, and the mixture is subsequently refluxed until HPLC monitoring indicates complete conversion (about 4 hours). The suspension obtained can be reacted further without further purification and without removal of the acetic acid formed as coproduct in the cleavage. The yield is (calculated from HPLC percentages by area) 99%.

후처리

  1. customprepared
  2. distillationAny chlorobenzene still present is distilled off azeotropically
  3. temperaturethe mixture is subsequently refluxed until HPLC monitoring
  4. customconversion (about 4 hours)
  5. customThe suspension obtained can
  6. customformed as coproduct in the cleavage

출처 및 근거

ORD 기록
ord-8a894b2f7d324691a6aeecead6b50a5b
출처 데이터셋
uspto-grants-2003_05
특허 번호
US06566546B2

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