Toluene → (2,3-Dichloro-6-nitrophenyl)methanol

HRID 41351

반응식

HRID 41351 반응식
C1(C)C=CC=CC=1.[Cl:8][C:9]1[C:16]([Cl:17])=[CH:15][CH:14]=[C:13]([N+:18]([O-:20])=[O:19])[C:10]=1[CH:11]=[O:12].[BH4-].[Na+]>CO>[Cl:8][C:9]1[C:16]([Cl:17])=[CH:15][CH:14]=[C:13]([N+:18]([O-:20])=[O:19])[C:10]=1[CH2:11][OH:12]

참가 물질

5

반응물 3

HCID 1140TolueneHCID 4311764Sodium borohydrideHCID 112182712,3-Dichloro-6-nitrobenzaldehyde

생성물 1

HCID 11160370(2,3-Dichloro-6-nitrophenyl)methanol

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
25 °C

실험 절차

To form 2,3-dichloro-6-nitrobenzylalcohol (compound XX) from 2,3-dichloro-6-nitro benzaldehyde (compound XIX), compound XIX is preferably solubilized in a solvent or solvent mixture such as toluene and methanol. The solution of compound XIX is added to a reducing solution such as sodium borohydride in an organic solvent over a period of time to maintain a reaction temperature below about 40° C., preferably 25° C. The reaction is preferably stirred for 24 hours at room temperature under nitrogen and then washed with water. After removing the aqueous layer the organic layer is azeotropically dried and concentrated forming 2,3-dichloro-6-nitrobenzylalcohol (compound XX).

후처리

  1. washwashed with water
  2. customAfter removing the aqueous layer the organic layer
  3. customis azeotropically dried
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-4b7498d6d4404f80b161caa37cf7fac8
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08530651B2

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