Methanol → Methyl 2-aminoisobutyrate hydrochloride

HRID 41355

반응식

HRID 41355 반응식
[NH2:1][C:2]([CH3:7])([CH3:6])[C:3]([OH:5])=[O:4].S(Cl)([Cl:10])=O.[CH3:12]O>>[ClH:10].[NH2:1][C:2]([CH3:7])([CH3:6])[C:3]([O:5][CH3:12])=[O:4]

참가 물질

4

반응물 3

HCID 887MethanolHCID 6119Aminoisobutyric acidHCID 24386Thionyl Chloride

생성물 1

HCID 13258034Methyl 2-aminoisobutyrate hydrochloride

실험 절차

To a suspension of 2-aminoisobutyric acid (25.0 g, 243 mmol) in methanol (300 mL) was added thionyl chloride (27.0 mL, 43.0 g, 365 mmol) and the reaction was heated at reflux for 12 hours. The resulting solution was concentrated and triturated with diethyl ether-tetrahydrofuran to yield the product as a white powder, 29.8 g (80%).

후처리

  1. temperaturethe reaction was heated
  2. temperatureat reflux for 12 hours
  3. concentrationThe resulting solution was concentrated
  4. customtriturated with diethyl ether-tetrahydrofuran

출처 및 근거

ORD 기록
ord-dec8121f10da4ad8809931f9538cbab1
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08530651B2

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