Phenol → Methyl-4-(trans-2-decenyloxy)-benzoate

HRID 413629노트

반응식

HRID 413629 반응식
C1(O)C=CC=CC=1.C(O)/C=C/CCCCCCC.CCOC(/N=N/C(OCC)=O)=O.[CH3:31][O:32][C:33](=[O:59])[C:34]1[CH:39]=[CH:38][C:37]([O:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][CH2:50]CCCCCCCC)=[CH:36][CH:35]=1>CCOCC>[CH3:31][O:32][C:33](=[O:59])[C:34]1[CH:39]=[CH:38][C:37]([O:40][CH2:41]/[CH:42]=[CH:43]/[CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][CH3:50])=[CH:36][CH:35]=1

참가 물질

6

반응물 4

HCID 996PhenolHCID 4189536Methyl 4-(octadecyloxy)benzoateHCID 53649422-Decenol, (2E)-HCID 5462977Diethyl azodicarboxylate

생성물 1

HCID 18521070Methyl-4-(trans-2-decenyloxy)-benzoate수율 65%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

Phenol 34 (486 mg, 3.2 mmol), 2-decenol 26g (500 mg, 3.2 mmol), TPP (965 mg, 3.68 mmol), and DEAD (641 mg, 3.68 mmol) in 32 ml ether were reacted according to the procedure for compound 35a. The crude product was purified via flash chromatography over silica gel with gradual elutions from 95/5-90/10 (v/v, Hex/EtOAc). Evaporation of solvent yielded 603 mg (65%) of colorless needles.

후처리

  1. customThe crude product was purified via flash chromatography over silica gel with gradual elutions from 95/5-90/10 (v/v, Hex/EtOAc)
  2. customEvaporation of solvent

출처 및 근거

ORD 기록
ord-3ccde8b6eb0e44c180f0d1201683a9ce
출처 데이터셋
uspto-grants-2003_05
특허 번호
US06569504B1

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