Phenol → Methyl-4-(trans-5-decenyloxy)-benzoate

HRID 413632노트

반응식

HRID 413632 반응식
CCOC(/N=N/C(OCC)=O)=O.C1(O)C=CC=CC=1.C(O)CCC/C=C/CCCC.[CH3:31][O:32][C:33](=[O:59])[C:34]1[CH:39]=[CH:38][C:37]([O:40][CH2:41][CH2:42][CH2:43][CH2:44][CH2:45][CH2:46][CH2:47][CH2:48][CH2:49][CH2:50]CCCCCCCC)=[CH:36][CH:35]=1>CCOCC>[CH3:31][O:32][C:33](=[O:59])[C:34]1[CH:39]=[CH:38][C:37]([O:40][CH2:41][CH2:42][CH2:43][CH2:44]/[CH:45]=[CH:46]/[CH2:47][CH2:48][CH2:49][CH3:50])=[CH:36][CH:35]=1

참가 물질

6

반응물 4

HCID 996PhenolHCID 4189536Methyl 4-(octadecyloxy)benzoateHCID 52832925-Decen-1-ol, (5E)-HCID 5462977Diethyl azodicarboxylate

생성물 1

HCID 18521058Methyl-4-(trans-5-decenyloxy)-benzoate수율 72%

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

DEAD (256 mg, 1.47 mmol), phenol 34 (194 mg, 1.28 mmol), alcohol 26j (200 mg, 1.28 mmol), and TPP (386 mg, 1.47 mmol) in 13 ml anhydrous ether were reacted according to the procedure for compound 35a. The crude product was purified via flash chromatography over silica gel with gradual elutions from 95/5 to 90/10 (v/v, Hex/EtOAc). Evaporation of the solvent yielded 266 mg (72%) of colorless liquid.

후처리

  1. customThe crude product was purified via flash chromatography over silica gel with gradual elutions from 95/5 to 90/10 (v/v, Hex/EtOAc)
  2. customEvaporation of the solvent

출처 및 근거

ORD 기록
ord-f88af62debeb4184a7fbf0620da384ed
출처 데이터셋
uspto-grants-2003_05
특허 번호
US06569504B1

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