3-(Trifluoromethyl)aniline → 3-(Trifluoromethyl)phenylcyanamide

HRID 413747

반응식

HRID 413747 반응식
[NH2:1][C:2]1[CH:3]=[C:4]([C:8]([F:11])([F:10])[F:9])[CH:5]=[CH:6][CH:7]=1.[N:12]#[C:13]Br>C(OCC)C>[NH:1]([C:2]1[CH:3]=[C:4]([C:8]([F:9])([F:10])[F:11])[CH:5]=[CH:6][CH:7]=1)[C:13]#[N:12]

참가 물질

4

반응물 2

HCID 73753-(Trifluoromethyl)anilineHCID 10476Cyanogen Bromide

생성물 1

HCID 110741023-(Trifluoromethyl)phenylcyanamide

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A mixture of 3-aminobenzotrifluoride (15.0 g, 93.1 mmol), cyanogen bromide (12.2 g, 129 mmol) and diethyl ether was stirred at reflux for 40 h. The crude mixture was purified by chromatography using silica gel and a mixture of petroleum ether and dichloromethane as eluent (1:1). The product was isolated as the free base. Yield 5.2 g, 25%.

후처리

  1. temperatureat reflux for 40 h
  2. customThe crude mixture was purified by chromatography
  3. additiona mixture of petroleum ether and dichloromethane as eluent (1:1)
  4. customThe product was isolated as the free base

출처 및 근거

ORD 기록
ord-7d40f5e34296423c91a8780b334a3abe
출처 데이터셋
uspto-grants-2003_05
특허 번호
US06569880B2

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