Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-(Trifluoromethyl)aniline → 3-(Trifluoromethyl)phenylcyanamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-(Trifluoromethyl)aniline | HCID 7375 | — |
| 반응물 | Cyanogen Bromide | HCID 10476 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 생성물 | 3-(Trifluoromethyl)phenylcyanamide | HCID 11074102 | — |
반응 단계
A mixture of 3-aminobenzotrifluoride (15.0 g, 93.1 mmol), cyanogen bromide (12.2 g, 129 mmol) and diethyl ether was stirred at reflux for 40 h. The crude mixture was purified by chromatography using silica gel and a mixture of petroleum ether and dichloromethane as eluent (1:1). The product was isolated as the free base. Yield 5.2 g, 25%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US06569880B2 |
| 출처 데이터셋 | uspto-grants-2003_05 |
| ORD ID | ord-7d40f5e34296423c91a8780b334a3abe |
| 출처 메모 | uspto-grants-2003_05 |