Water → 3-(4-Trifluoromethylphenylthio)propanal

HRID 414030

반응식

HRID 414030 반응식
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:8]=[CH:7][C:6]([SH:9])=[CH:5][CH:4]=1.[CH:12]([CH:14]=[CH2:15])=[O:13].O>C1COCC1.C(N(CC)CC)C>[F:11][C:2]([F:1])([F:10])[C:3]1[CH:4]=[CH:5][C:6]([S:9][CH2:15][CH2:14][CH:12]=[O:13])=[CH:7][CH:8]=1

참가 물질

6

반응물 3

HCID 962WaterHCID 7847AcroleinHCID 1366534-(Trifluoromethyl)thiophenol

생성물 1

HCID 143479823-(4-Trifluoromethylphenylthio)propanal수율 99.6%

시약·촉매·용매 2

HCID 8471Triethylamine촉매HCID 8028Tetrahydrofuran용매

실험 절차

Ten grams of 4-trifluoromethylthiophenol was dissolved in 15 ml of THF, and after adding 4.0 g of 95% acrolein under ice-cooling, 0.1 g of triethylamine was added while thoroughly stirring the reaction solution. After stirring for 1.5 hours under ice-cooling, the reaction solution was poured into water and extracted with ether. The ether layer was washed with water and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to obtain 13.1 g of 3-(4-trifluoromethylphenylthio)propionaldehyde.

후처리

  1. temperaturecooling
  2. stirringAfter stirring for 1.5 hours under ice-
  3. temperaturecooling
  4. extractionextracted with ether
  5. washThe ether layer was washed with water
  6. dry with materialdried over anhydrous magnesium sulfate
  7. customThe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-8fffb9f5120448a293a9012ddff4bfe1
출처 데이터셋
uspto-grants-1988_12
특허 번호
US04789396

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