Water → 3-(4-Trifluoromethylphenylthio)propanal
반응식
[F:1][C:2]([F:11])([F:10])[C:3]1[CH:8]=[CH:7][C:6]([SH:9])=[CH:5][CH:4]=1.[CH:12]([CH:14]=[CH2:15])=[O:13].O>C1COCC1.C(N(CC)CC)C>[F:11][C:2]([F:1])([F:10])[C:3]1[CH:4]=[CH:5][C:6]([S:9][CH2:15][CH2:14][CH:12]=[O:13])=[CH:7][CH:8]=1참가 물질
6
실험 절차
Ten grams of 4-trifluoromethylthiophenol was dissolved in 15 ml of THF, and after adding 4.0 g of 95% acrolein under ice-cooling, 0.1 g of triethylamine was added while thoroughly stirring the reaction solution. After stirring for 1.5 hours under ice-cooling, the reaction solution was poured into water and extracted with ether. The ether layer was washed with water and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to obtain 13.1 g of 3-(4-trifluoromethylphenylthio)propionaldehyde.
후처리
- temperaturecooling
- stirringAfter stirring for 1.5 hours under ice-
- temperaturecooling
- extractionextracted with ether
- washThe ether layer was washed with water
- dry with materialdried over anhydrous magnesium sulfate
- customThe solvent was removed under reduced pressure
출처 및 근거
- ORD 기록
- ord-8fffb9f5120448a293a9012ddff4bfe1
- 출처 데이터셋
- uspto-grants-1988_12
- 특허 번호
- US04789396
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