Hydrazine hydrate (1:1) → 6-Chloro-1,3-dihydroindol-2-one

HRID 414262

반응식

HRID 414262 반응식
[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6](=O)[C:7](=[O:11])[NH:8]2)=[CH:4][CH:3]=1.O.NN.[O-]CC.[Na+]>C(O)C>[Cl:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][C:7](=[O:11])[NH:8]2)=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 24654Hydrazine hydrate (1:1)HCID 2413316-Chloroindoline-2,3-dioneHCID 2723922Sodium ethoxide

생성물 1

HCID 7363446-Chloro-1,3-dihydroindol-2-one수율 42.5%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Reaction of 36.2 g of 6-chloroisatin with hydrazine hydrate followed by sodium ethoxide in ethanol, substantially according to C above, afforded 14.2 g of 6-chloro-2-oxindole, m.p. 196°-198° C.

출처 및 근거

ORD 기록
ord-f162087dfbfb495399daf14691244f74
출처 데이터셋
uspto-grants-1988_12
특허 번호
US04791131

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