Pyridine → Pentafluorobenzyl bromide

HRID 414292

반응식

HRID 414292 반응식
P(Br)(Br)[Br:2].[F:5][C:6]1[C:13]([F:14])=[C:12]([F:15])[C:11]([F:16])=[C:10]([F:17])[C:7]=1[CH2:8]O.N1C=CC=CC=1.C(=O)(O)[O-].[Na+]>C1(C)C=CC=CC=1>[F:5][C:6]1[C:13]([F:14])=[C:12]([F:15])[C:11]([F:16])=[C:10]([F:17])[C:7]=1[CH2:8][Br:2]

참가 물질

6

반응물 4

HCID 1049PyridineHCID 99232,3,4,5,6-Pentafluorobenzyl AlcoholHCID 24614Phosphorus tribromideHCID 516892Sodium Bicarbonate

생성물 1

HCID 74484Pentafluorobenzyl bromide

시약·촉매·용매 1

HCID 1140Toluene용매2회

반응 조건

온도
0 °C

실험 절차

A mixture of phosphorus tribromide (2.1 g) and toluene (1 cm3) was added dropwise to a solution of 2,3,4,5,6-pentafluorobenzylalcohol (3.4 g) and pyridine (0.21 g) in toluene (10 cm3) at 0° C. The reaction mixture was stirred at 0° C. for 45 minutes, then at the ambient temperature (ca. 20° C.) for 75 minutes, and was then added to an excess of saturated sodium bicarbonate solution. The products were extracted into diethyl ether, and the combined ether layers dried and concentrated by evaporation under reduced pressure. The residual solution (still containing toluene) was passed through a plug of silica gel.

후처리

  1. waitat the ambient temperature (ca. 20° C.) for 75 minutes
  2. extractionThe products were extracted into diethyl ether
  3. dry with materialthe combined ether layers dried
  4. concentrationconcentrated by evaporation under reduced pressure

출처 및 근거

ORD 기록
ord-fb35ab862083431995ce10c40a743973
출처 데이터셋
uspto-grants-1988_12
특허 번호
US04791139

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